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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM114666
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer
IC50
9237±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM114666
Synonyms:
7,9-diketo-8-methyl-6,11-dihydro-5bH-indolizino[1,2-b]quinoline-8-carboxylic acid ethyl ester | 8-methyl-7,9-dioxo-6,11-dihydro-5bH-indolizino[1,2-b]quinoline-8-carboxylic acid ethyl ester | MLS002920754 | SMR001798340 | cid_288099 | ethyl 8-methyl-7,9-bis(oxidanylidene)-6,11-dihydro-5bH-indolizino[1,2-b]quinoline-8-carboxylate | ethyl 8-methyl-7,9-dioxo-6,11-dihydro-5bH-indolizino[1,2-b]quinoline-8-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H18N2O4
Mol. Mass.:
338.3572
SMILES:
CCOC(=O)C1(C)C(=O)CC2N(Cc3cc4ccccc4nc23)C1=O
Structure:
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