Reaction Details Report a problem with these data
Target
Kinesin-like protein KIF11 [1-973]
Ligand
BDBM115177
Substrate
n/a
Meas. Tech.
Microtubule-activated ATPase Kinetic Assay
IC50
1.72e+3±n/a nM
Citation
Carbajales, C; Prado, MÁ; Gutirrez-de-Tern, H; Gutiérrez-de-Terán, A; Azuaje, J; Novio, S; Nuez, MJ; Nuñez, B; Fernández-García, E; Garca-Mera, X; García-Mera, P; Sánchez-Lazo, M; Coelho, A Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction. Chembiochem 15:1471-80 (2014) [PubMed] Article
More Info.:
Target
Name:
Kinesin-like protein KIF11 [1-973]
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin-5 motor protein (KSP) | TRIP5
Type:
Protein
Mol. Mass.:
109974.43
Organism:
Homo sapiens (Human)
Description:
P52732[1-973]
Residue:
973
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETI
Inhibitor
Name:
BDBM115177
Synonyms:
(−)-Ethyl 2-[2-(2-benzoyl-5,6-dibromo-1H-benzo[d]imidazol-1-yl)pentanamido]acetate (Compound 23) | (+)-Ethyl 2-[2-(2-benzoyl-5,6-dibromo-1H-benzo[d]imidazol-1-yl)pentanamido] acetate (Compound 22)
Type:
Small organic molecule
Emp. Form.:
C23H23Br2N3O4
Mol. Mass.:
565.254
SMILES:
CCCC(C(=O)NCC(=O)OCC)n1c(nc2cc(Br)c(Br)cc12)C(=O)c1ccccc1