Reaction Details Report a problem with these data
Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM119069
Substrate
n/a
Ki
1.6e+4±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
MURA_ENTCC | MurA (E. cloacae) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | murA | murZ
Type:
Protein
Mol. Mass.:
44773.01
Organism:
Enterobacter cloacae (Enterobacteria)
Description:
E. cloacae MurA
Residue:
419
Sequence:
MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQLGTKVERNGSVWIDASNVNNFSAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHIFGLEKLGAEIKLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
  
Inhibitor
Name:
BDBM119069
Synonyms:
T6361 (compound 4)
Type:
Small organic molecule
Emp. Form.:
C34H36N2O10S2
Mol. Mass.:
696.787
SMILES:
CN([C@@H](CCCC(O)=O)C(O)=O)C(=O)C1CC(CCC1NS(=O)(=O)c1cccc2ccccc12)OS(=O)(=O)c1cccc2ccccc12 |r|
Structure:
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