Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM119106
Substrate
n/a
IC50
4.5e+4±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:
Ligase
Mol. Mass.:
46963.02
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
  
Inhibitor
Name:
BDBM119106
Synonyms:
MurD inhibitor (compound 48)
Type:
Small organic molecule
Emp. Form.:
C16H14N2O6S2
Mol. Mass.:
394.422
SMILES:
OC(=O)CC[C@@H](NC(=O)c1ccc(C=C2SC(O)=NC2=S)cc1)C(O)=O |r,w:13.12,c:17|
Structure:
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