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Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM119107
Substrate
n/a
IC50
6.4e+3±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
MURD_STAAU | MurD (S. aureus) | murD
Type:
Protein
Mol. Mass.:
49837.61
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurD
Residue:
449
Sequence:
MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVVSGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIIDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFDELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSPACASWDQYSTFEERGEKFIERFRAHLPSY
  
Inhibitor
Name:
BDBM119107
Synonyms:
MurD/E inhibitor (compound 49)
Type:
Small organic molecule
Emp. Form.:
C23H21N3O6S2
Mol. Mass.:
499.559
SMILES:
OC(=O)CC[C@@H](NC(=O)c1cccc(NCc2ccc(C=C3SC(S)=NC3=O)cc2)c1)C(O)=O |r,w:20.19,c:24|
Structure:
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