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Target
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Ligand
BDBM119122
Substrate
n/a
IC50
1.6e+4±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Synonyms:
JW0083 | MURE_ECOLI | Meso-A2pm-adding enzyme | Meso-diaminopimelate-adding enzyme | MurE (E. coli) | UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase | UDP-MurNAc-tripeptide synthetase | UDP-N-acetylmuramyl-tripeptide synthetase | murE
Type:
Protein
Mol. Mass.:
53333.42
Organism:
Escherichia coli UMNK88 (Enterobacteria)
Description:
P22188
Residue:
495
Sequence:
MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA
  
Inhibitor
Name:
BDBM119122
Synonyms:
MurA/B/C/D/E inhibitor (compound 67)
Type:
Small organic molecule
Emp. Form.:
C22H13F3O3
Mol. Mass.:
382.332
SMILES:
FC(F)(F)c1ccc(cc1)C1C(=O)OC(=Cc2cccc3ccccc23)C1=O |w:15.16|
Structure:
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