Reaction Details
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DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM50303955
Substrate
n/a
Meas. Tech.
Electrophoretic Mobility Shift Assays (EMSAs)
pH
7.5±n/a
IC50
2.0e+4±n/a nM
Comments
extracted
Citation
Zhang, J; Luo, M; Marasco, D; Logsdon, D; LaFavers, KA; Chen, Q; Reed, A; Kelley, MR; Gross, ML; Georgiadis, MM Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited. Biochemistry 52:2955-66 (2013) [PubMed] Article More Info.:
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
Inhibitor
Name:
BDBM50303955
Synonyms:
(E)-3-(5,6-Dimethoxy-3-methyl-14-dioxocyclohexa-25-dienyl)-2-nonylpropenoic Acid | CHEMBL578390 | E3330 | US9624235, Compound E3330
Type:
Small organic molecule
Emp. Form.:
C21H30O6
Mol. Mass.:
378.4593
SMILES:
CCCCCCCCCC(=CC1=C(C)C(=O)C(OC)=C(OC)C1=O)C(O)=O |w:10.10,c:11,t:18|
Structure:
