Reaction Details Report a problem with these data
Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM119358
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
Temperature
301.15±n/a K
IC50
6±n/a nM
Comments
extracted
Citation
 Luk, K; Soth, M Imidazo pyrazines US Patent  US8673905 Publication Date 3/18/2014 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM119358
Synonyms:
US8673905, 73
Type:
Small organic molecule
Emp. Form.:
C24H27N7
Mol. Mass.:
413.5181
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1nccn2c(cnc12)-c1cccc(NCc2ccccc2)n1 |r,wU:1.0,wD:4.7,(-9.04,-3.06,;-8.27,-1.73,;-9.04,-.39,;-8.27,.94,;-6.73,.94,;-5.96,-.39,;-6.73,-1.73,;-5.96,2.27,;-4.42,2.27,;-3.65,3.61,;-2.11,3.61,;-1.34,2.27,;-2.11,.94,;-1.63,-.53,;-2.88,-1.43,;-4.12,-.53,;-3.65,.94,;-.3,-1.3,;-.3,-2.84,;1.04,-3.61,;2.37,-2.84,;2.37,-1.3,;3.7,-.53,;5.04,-1.3,;6.37,-.53,;7.7,-1.3,;9.04,-.53,;9.04,1.01,;7.7,1.78,;6.37,1.01,;1.04,-.53,)|
Structure:
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