Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM119437
Substrate
n/a
Meas. Tech.
Binding Assay
pH
6±n/a
Temperature
303.15±n/a K
Ki
3.8±n/a nM
Comments
extracted
Citation
 Hagihara, M; Yoneda, K; Okanari, E; Shigetomi, M Medical composition for treatment or prophylaxis of glaucoma US Patent  US8685986 Publication Date 4/1/2014 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM119437
Synonyms:
US8685986, 11
Type:
Small organic molecule
Emp. Form.:
C22H17FN4O3S
Mol. Mass.:
436.459
SMILES:
ONC(=O)c1ccc(CNC(=O)c2[nH]c(cc2-c2ccc(F)cc2)-c2cccs2)nc1
Structure:
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