Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM119616
Substrate
n/a
Meas. Tech.
Radioligand Binding
Temperature
277.15±n/a K
Ki
2149±n/a nM
Comments
extracted
Citation
 Branstetter, BJ; Letavic, MA; Ly, KS; Rudolph, DA; Savall, BM; Shah, CR; Shireman, BT Fused heterocyclic compounds as orexin receptor modulators US Patent  US8680275 Publication Date 3/25/2014 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM119616
Synonyms:
US8680275, 173
Type:
Small organic molecule
Emp. Form.:
C24H27N5OS
Mol. Mass.:
433.569
SMILES:
Cc1nc(C(=O)N2CC[C@H]3CN([C@H]3C2)c2nc(C)cc(C)n2)c(s1)-c1ccc(C)cc1 |r|
Structure:
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