Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM119806
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±0
Temperature
273.15±n/a K
Ki
27±0.0 nM
Citation
 Flessner, T; Böss, F; Hafner, F; Luithle, J; Methfessel, C; Telan, L N-biarylamides US Patent  US8691840 Publication Date 4/8/2014 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM119806
Synonyms:
US8691840, 15
Type:
Small organic molecule
Emp. Form.:
C27H26FN3O2
Mol. Mass.:
443.5126
SMILES:
Fc1cccc(c1)C(=O)Nc1ccc(cc1)-c1ccc(NC(=O)[C@H]2CN3CCC2CC3)cc1 |r,wU:23.24,(10.67,1.93,;9.34,2.7,;9.34,4.24,;8,5.01,;6.67,4.24,;6.67,2.7,;8,1.93,;5.33,1.93,;5.33,.39,;4,2.7,;2.67,1.93,;2.67,.39,;1.33,-.39,;,.39,;,1.93,;1.33,2.7,;-1.33,-.39,;-1.33,-1.93,;-2.67,-2.7,;-4,-1.93,;-5.33,-2.7,;-6.67,-1.93,;-6.67,-.39,;-8,-2.7,;-8,-4.24,;-9.34,-5.01,;-10.67,-4.24,;-10.67,-2.7,;-9.34,-1.93,;-8.57,-3.26,;-10.05,-3.66,;-4,-.39,;-2.67,.39,)|
Structure:
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