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Target
DNA primase
Ligand
BDBM50364890
Substrate
n/a
Meas. Tech.
Quatitative Inhibition Analysis Assay
pH
8.8±n/a
IC50
6.9e+4± 5e+3 nM
Comments
extracted
Citation
 Biswas, T; Green, KD; Garneau-Tsodikova, S; Tsodikov, OV Discovery of inhibitors of Bacillus anthracis primase DnaG. Biochemistry 52:6905-10 (2013) [PubMed]  Article 
Target
Name:
DNA primase
Synonyms:
DNA primase (Mtb DnaG) | DNAG_MYCTO | dnaG
Type:
Protein
Mol. Mass.:
69595.17
Organism:
Mycobacterium tuberculosis
Description:
M. tuberculosis UT205
Residue:
639
Sequence:
MSGRISDRDIAAIREGARIEDVVGDYVQLRRAGADSLKGLCPFHNEKSPSFHVRPNHGHFHCFGCGEGGDVYAFIQKIEHVSFVEAVELLADRIGHTISYTGAATSVQRDRGSRSRLLAANAAAAAFYAQALQSDEAAPARQYLTERSFDAAAARKFGCGFAPSGWDSLTKHLQRKGFEFEELEAAGLSRQGRHGPMDRFHRRLLWPIRTSAGEVVGFGARRLFDDDAMEAKYVNTPETLLYKKSSVMFGIDLAKRDIAKGHQAVVVEGYTDVMAMHLAGVTTAVASCGTAFGGEHLAMLRRLMMDDSFFRGELIYVFDGDEAGRAAALKAFDGEQKLAGQSFVAVAPDGMDPCDLRLKCGDAALRDLVARRTPLFEFAIRAAIAEMDLDSAEGRVAALRRCVPMVGQIKDPTLRDEYARQLAGWVGWADVAQVIGRVRGEAKRTKHPRLGRLGSTTIARAAQRPTAGPPTELAVRPDPRDPTLWPQREALKSALQYPALAGPVFDALTVEGFTHPEYAAVRAAIDTAGGTSAGLSGAQWLDMVRQQTTSTVTSALISELGVEAIQVDDDKLPRYIAGVLARLQEVWLGRQIAEVKSKLQRMSPIEQGDEYHALFGDLVAMEAYRRSLLEQASGDDLTA
  
Inhibitor
Name:
BDBM50364890
Synonyms:
Amixin IC | TILORONE | cid_5475
Type:
Small organic molecule
Emp. Form.:
C25H34N2O3
Mol. Mass.:
410.5491
SMILES:
CCN(CC)CCOc1ccc2-c3ccc(OCCN(CC)CC)cc3C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: