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Target
DNA primase
Ligand
BDBM50366826
Substrate
n/a
Meas. Tech.
Quatitative Inhibition Analysis Assay
pH
8.8±n/a
IC50
7.5e+4± 1.0e+4 nM
Comments
extracted
Citation
 Biswas, T; Green, KD; Garneau-Tsodikova, S; Tsodikov, OV Discovery of inhibitors of Bacillus anthracis primase DnaG. Biochemistry 52:6905-10 (2013) [PubMed]  Article 
Target
Name:
DNA primase
Synonyms:
DNA primase (Ba DnaG)
Type:
Protein
Mol. Mass.:
68258.37
Organism:
Bacillus anthracis (Firmicutes)
Description:
A0A6L8PXB3
Residue:
598
Sequence:
MGNRIPEEVVEQIRTSSDIVEVIGEYVQLRKQGRNYFGLCPFHGENSPSFSVSSDKQIFHCFGCGEGGNVFSFLMKMEGLAFTEAVQKLGERNGIAVAEYTSGQGQQEDISDDTVIMQQAHELLKKYYHHLLVNTEEGNEALSYLLKRGITKEMIEKFEIGYASPAWDAATKILQKRGLSLSSMEQAGLLIRSEKDGSHYDRFRGRVMFPIYTLQGKVIAFSGRALGDDTPKYLNSPETPIFHKSKLLYNFHQARPFIRKRGQVVLFEGYADVLAAVKSGVEEAVATMGTALTEEQAKLLRRNVETVVLCYDGDKAGREATMKAGQLLLQVGCQVKVTSLPDKLDPDEYVQQYGTTAFENLVKSSISFVGFKINYLRLGKNLQDESGKEEYVKSVLKELSLLQDAMQAESYLKSLSQEFSYSMETLLNQLHQYRKEQKVQQKQVKQVSKPSQIVQTKPKLTGFERAEREIIYHMLQSPEVAVRMESHIEDFHTEEHKGILYELYAYYEKGNEPSVGTFLSWLSDEKLKNIITDISTDEFINPEYTEEVLQSHLETLRRHQEKLEKMEIIFKIKQMEKTDPVEAAKYYVAYLQNQKARK
  
Inhibitor
Name:
BDBM50366826
Synonyms:
DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaquin
Type:
Small organic molecule
Emp. Form.:
C18H20FN3O4
Mol. Mass.:
361.3675
SMILES:
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r|
Structure:
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