Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM120822
Substrate
n/a
Meas. Tech.
Enzymatic activity assay
pH
6±n/a
Temperature
310.15±n/a K
Ki
0.146±0.014 nM
Comments
extracted
Citation
 Raghav, N; Garg, S N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H. Bioorg Chem 57:43-50 (2014) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
36777.57
Organism:
Capra hircus (Goat)
Description:
n/a
Residue:
335
Sequence:
MWQLLATLSCLLVLTSARSSLHFPPLSDEMVNYVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADMVLPDSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSKGRVNVEVSAEDMLTCCGSECGDGCNGGFPSGAWNFWTKKGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPSYKDDKHFGCSSYSVSSNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEMMGGHAIRILGWGVENDTPYWLVGNSWNTDWGDKGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM120822
Synonyms:
N-formyl-5-(-3'-chlorophenyl)-3-phenylpyrazoline (1c)
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O
Mol. Mass.:
284.74
SMILES:
Clc1cccc(c1)C1CC(=NN1C=O)c1ccccc1 |c:10|
Structure:
Search PDB for entries with ligand similarity: