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Target
D(3) dopamine receptor
Ligand
BDBM121466
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
1.34±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent  US8722683 Publication Date 5/13/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM121466
Synonyms:
US8722683, 13
Type:
Small organic molecule
Emp. Form.:
C25H34N4O4
Mol. Mass.:
454.5619
SMILES:
Cc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCN(CC3)c3cccc4OCOc34)CC2)on1 |r,wU:8.7,wD:11.11,(11.3,3.57,;9.97,2.8,;9.49,1.33,;7.95,1.33,;7.18,,;5.64,,;4.87,-1.33,;4.87,1.33,;3.33,1.33,;2.56,,;1.02,,;.25,1.33,;-1.29,1.33,;-2.06,,;-3.6,,;-4.37,-1.33,;-5.91,-1.33,;-6.68,,;-5.91,1.33,;-4.37,1.33,;-8.22,,;-8.99,1.33,;-10.53,1.33,;-11.3,,;-10.53,-1.33,;-11.01,-2.8,;-9.76,-3.7,;-8.51,-2.8,;-8.99,-1.33,;1.02,2.67,;2.56,2.67,;7.47,2.8,;8.72,3.7,)|
Structure:
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