Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM121475
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.06±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent  US8722683 Publication Date 5/13/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM121475
Synonyms:
US8722683, 22
Type:
Small organic molecule
Emp. Form.:
C24H35N3O4
Mol. Mass.:
429.5524
SMILES:
O=C(CC1COC1)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc3OCOc23)CC1 |r,wU:8.8,wD:11.12,(5.8,-.82,;6.57,.52,;8.11,.52,;8.88,-.82,;8.48,-2.3,;9.97,-2.7,;10.37,-1.21,;5.8,1.85,;4.26,1.85,;3.49,.52,;1.95,.52,;1.18,1.85,;-.36,1.85,;-1.13,.52,;-2.67,.52,;-3.44,-.82,;-4.98,-.82,;-5.75,.52,;-4.98,1.85,;-3.44,1.85,;-7.29,.52,;-8.06,1.85,;-9.6,1.85,;-10.37,.52,;-9.6,-.82,;-10.07,-2.28,;-8.83,-3.19,;-7.58,-2.28,;-8.06,-.82,;1.95,3.19,;3.49,3.19,)|
Structure:
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