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Target
D(3) dopamine receptor
Ligand
BDBM121476
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.5±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent  US8722683 Publication Date 5/13/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM121476
Synonyms:
US8722683, 23
Type:
Small organic molecule
Emp. Form.:
C27H41N3O4
Mol. Mass.:
471.6321
SMILES:
CO[C@@H]1CC[C@@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(CC3)c3cccc4OCOc34)CC2)C1 |r,wU:10.9,5.5,wD:13.13,2.1,(11.3,-3.89,;11.3,-2.35,;9.97,-1.58,;8.72,-2.48,;7.47,-1.58,;7.95,-.11,;7.18,1.22,;5.64,1.22,;4.87,-.11,;4.87,2.55,;3.33,2.55,;2.56,1.22,;1.02,1.22,;.25,2.55,;-1.29,2.55,;-2.06,1.22,;-3.6,1.22,;-4.37,-.11,;-5.91,-.11,;-6.68,1.22,;-5.91,2.55,;-4.37,2.55,;-8.22,1.22,;-8.99,2.55,;-10.53,2.55,;-11.3,1.22,;-10.53,-.11,;-11.01,-1.58,;-9.76,-2.48,;-8.51,-1.58,;-8.99,-.11,;1.02,3.89,;2.56,3.89,;9.49,-.11,)|
Structure:
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