Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM121505
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
3.56±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent  US8722683 Publication Date 5/13/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM121505
Synonyms:
US8722683, 52
Type:
Small organic molecule
Emp. Form.:
C24H35N3O5S
Mol. Mass.:
477.617
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc3OCOc23)CC1)C1CCS(=O)(=O)C1 |r,wU:3.2,wD:6.6,(4.98,-.82,;5.75,.52,;4.98,1.85,;3.44,1.85,;2.66,.52,;1.13,.52,;.36,1.85,;-1.18,1.85,;-1.95,.52,;-3.49,.52,;-4.26,-.82,;-5.8,-.82,;-6.57,.52,;-5.8,1.85,;-4.26,1.85,;-8.11,.52,;-8.88,1.85,;-10.42,1.85,;-11.19,.52,;-10.42,-.82,;-10.9,-2.28,;-9.65,-3.19,;-8.41,-2.28,;-8.88,-.82,;1.13,3.19,;2.66,3.19,;7.28,.52,;8.19,-.73,;9.65,-.25,;9.65,1.29,;11.19,1.29,;10.42,2.62,;8.19,1.76,)|
Structure:
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