Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM121524
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.01±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent  US8722683 Publication Date 5/13/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM121524
Synonyms:
US8722683, 71
Type:
Small organic molecule
Emp. Form.:
C28H36N4O3
Mol. Mass.:
476.6104
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc3OCOc23)CC1)N1CCc2ccccc12 |r,wU:3.2,wD:6.6,(5.17,-.78,;5.94,.56,;5.17,1.89,;3.63,1.89,;2.86,.56,;1.32,.56,;.55,1.89,;-.99,1.89,;-1.76,.56,;-3.3,.56,;-4.07,-.78,;-5.61,-.78,;-6.38,.56,;-5.61,1.89,;-4.07,1.89,;-7.92,.56,;-8.69,1.89,;-10.23,1.89,;-11,.56,;-10.23,-.78,;-10.7,-2.24,;-9.46,-3.15,;-8.21,-2.24,;-8.69,-.78,;1.32,3.23,;2.86,3.23,;7.48,.56,;8.39,1.8,;9.85,1.33,;9.85,-.21,;11,-1.24,;10.68,-2.75,;9.21,-3.23,;8.07,-2.19,;8.39,-.69,)|
Structure:
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