Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM121527
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.44±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperazine compounds US Patent  US8722683 Publication Date 5/13/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM121527
Synonyms:
US8722683, 74
Type:
Small organic molecule
Emp. Form.:
C26H39N3O4
Mol. Mass.:
457.6056
SMILES:
OC[C@H]1C[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCN(CC3)c3cccc4OCOc34)CC2)C1 |r,wU:9.8,2.1,wD:12.12,4.4,(11.28,4.13,;9.83,4.13,;9.06,2.79,;9.46,1.31,;7.97,.91,;7.2,-.43,;5.66,-.43,;4.89,-1.76,;4.89,.91,;3.35,.91,;2.58,-.43,;1.04,-.43,;.27,.91,;-1.27,.91,;-2.04,-.43,;-3.58,-.43,;-4.35,-1.76,;-5.89,-1.76,;-6.66,-.43,;-5.89,.91,;-4.35,.91,;-8.2,-.43,;-8.97,.91,;-10.51,.91,;-11.28,-.43,;-10.51,-1.76,;-10.99,-3.22,;-9.74,-4.13,;-8.49,-3.22,;-8.97,-1.76,;1.04,2.24,;2.58,2.24,;7.57,2.4,)|
Structure:
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