Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM123100
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7±n/a
Ki
2.7±n/a nM
Comments
extracted
Citation
Odén, LS; Nilsson, M; Kahnberg, P; Samuelsson, B; Grabowska, U Protease inhibitors US Patent US8735395 Publication Date 5/27/2014
More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM123100
Synonyms:
US10723709, Example 4 | US11312693, Example 4 | US8735395, 4
Type:
Small organic molecule
Emp. Form.:
C31H40FN5O4S
Mol. Mass.:
597.744
SMILES:
[#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-c1ccc(cc1)-c1nc(sc1F)-[#7]-1-[#6]-[#6]-[#7](-[#6])-[#6]-[#6]-1)-[#6](=O)-[#7]-1-[#6]-[#6@@H](\[#6]=[#6](\[#6])-[#6])-[#6@H]-2-[#8]-[#6]-[#6](=O)-[#6@@H]-1-2 |r|