Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM123099
Substrate
n/a
Meas. Tech.
Enzyme Assay
Ki
1400±n/a nM
Citation
 Odén, LS; Nilsson, M; Kahnberg, P; Samuelsson, B; Grabowska, U Protease inhibitors US Patent  US8735395 Publication Date 5/27/2014 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM123099
Synonyms:
US10723709, Example 3 | US11312693, Example 3 | US8735395, 3
Type:
Small organic molecule
Emp. Form.:
C29H34FN5O4S
Mol. Mass.:
567.675
SMILES:
CC(C)C[C@H](NC(=O)c1ccc(-c2csc(n2)N2CCN(C)CC2)c(F)c1)C(=O)N1C[C@@H](C#C)[C@H]2OCC(=O)[C@@H]12 |r|
Structure:
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