Reaction Details Report a problem with these data
Target
Core-binding factor subunit beta
Ligand
BDBM50180735
Substrate
n/a
Meas. Tech.
FRET Assay
IC50
2500±n/a nM
Citation
 Bushweller, JH; Grembecka, J; Illendula, A; Dixon, L Inhibitors of inv(16) leukemia US Patent  US8748618 Publication Date 6/10/2014 
Target
Name:
Core-binding factor subunit beta
Synonyms:
CBFB | Core-binding factor subunit beta (CBFB) | PEBB_HUMAN
Type:
Enzyme
Mol. Mass.:
21507.90
Organism:
Homo sapiens (Human)
Description:
Q13951
Residue:
182
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP
  
Inhibitor
Name:
BDBM50180735
Synonyms:
5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5-fluoro-2-pyridin-2-yl-1H-benzoimidazole | CHEMBL199982 | US8748618, LD-1-31
Type:
Small organic molecule
Emp. Form.:
C12H8FN3
Mol. Mass.:
213.2104
SMILES:
Fc1ccc2nc([nH]c2c1)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: