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Target
Core-binding factor subunit beta
Ligand
BDBM123674
Substrate
n/a
Meas. Tech.
FRET Assay
IC50
760±n/a nM
Citation
 Bushweller, JH; Grembecka, J; Illendula, A; Dixon, L Inhibitors of inv(16) leukemia US Patent  US8748618 Publication Date 6/10/2014 
Target
Name:
Core-binding factor subunit beta
Synonyms:
CBFB | Core-binding factor subunit beta (CBFB) | PEBB_HUMAN
Type:
Enzyme
Mol. Mass.:
21507.90
Organism:
Homo sapiens (Human)
Description:
Q13951
Residue:
182
Sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP
  
Inhibitor
Name:
BDBM123674
Synonyms:
US8748618, AI-4-48
Type:
Small organic molecule
Emp. Form.:
C13H7ClF3N3
Mol. Mass.:
297.663
SMILES:
FC(F)(F)c1cc(Cl)c2[nH]c(nc2c1)-c1ccccn1
Structure:
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