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Target
Proteasome subunit beta type-5
Ligand
BDBM123813
Substrate
n/a
Meas. Tech.
20S proteasome chymotrypsin-like inhibition assay
IC50
1.01e+3± 1.0e+2 nM
Citation
 Zhang, J; Han, M; Ma, X; Xu, L; Cao, J; Zhou, Y; Li, J; Liu, T; Hu, Y Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of ??????-amino Acids. Chem Biol Drug Des 84:497-504 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM123813
Synonyms:
4-Methoxy-N-{3-{S-4-methyl-1-[S-4-methyl-1-(R-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino]-1-oxopentan-2-ylamino}-3-oxo-1-phenylpropyl} benzamide (21e)
Type:
Small organic molecule
Emp. Form.:
C32H43N3O6
Mol. Mass.:
565.7003
SMILES:
COc1ccc(cc1)C(=O)NC(CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1)c1ccccc1 |r|
Structure:
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