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Target
Somatostatin receptor type 3
Ligand
BDBM124131
Substrate
n/a
Meas. Tech.
Binding Scintillation Proximity Assay
pH
7.8±n/a
Temperature
298.15±n/a K
IC50
1.2±n/a nM
Comments
extracted
Citation
 Guo, L; Hagmann, WK; He, S; Lai, Z; Liu, J; Nargund, RP; Shah, SK; Truong, QT Oxadiazole beta carboline derivatives as antidiabetic compounds US Patent  US8754099 Publication Date 6/17/2014 
Target
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SS-3-R | SS3-R | SS3R | SSR-28 | SSR3_HUMAN | SSTR3 | Somatostatin receptor type 3 (SSTR3)
Type:
Protein
Mol. Mass.:
45855.97
Organism:
Homo sapiens (Human)
Description:
P32745
Residue:
418
Sequence:
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
  
Inhibitor
Name:
BDBM124131
Synonyms:
US8754099, 22
Type:
Small organic molecule
Emp. Form.:
C30H30FN7O2
Mol. Mass.:
539.6033
SMILES:
COC1CC2C(C1)C2C1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)c(C)n1)c1nnc(C)o1 |r,wD:10.25,(-6.61,-7.12,;-5.07,-7.12,;-4.3,-5.78,;-5.07,-4.45,;-4.3,-3.12,;-1.99,-4.45,;-2.76,-5.78,;-2.76,-3.12,;-1.99,-1.78,;-.65,-1.01,;-.65,.53,;-1.99,1.3,;-3.32,.53,;-3.32,-1.01,;-4.79,-1.49,;-5.69,-.24,;-7.22,-.08,;-7.85,1.32,;-6.94,2.57,;-5.41,2.41,;-4.79,1,;.68,1.3,;1.16,2.76,;2.7,2.76,;3.17,1.3,;1.93,.39,;3.78,3.85,;3.39,5.34,;4.48,6.43,;5.96,6.03,;7.05,7.12,;6.36,4.54,;7.85,4.14,;5.27,3.45,;-.65,-2.55,;-.65,-4.09,;.81,-4.57,;1.72,-3.32,;3.26,-3.32,;.81,-2.08,)|
Structure:
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