Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase-like protein
Ligand
BDBM124974
Substrate
n/a
Meas. Tech.
Fluorometric Assay
pH
8±n/a
Ki
11±n/a nM
IC50
580±n/a nM
Comments
extracted
Citation
 Buchholz, M; Heiser, U; Hamann, A Inhibitors of glutaminyl cyclase US Patent  US8772508 Publication Date 7/8/2014 
Target
Name:
Glutaminyl-peptide cyclotransferase-like protein
Synonyms:
Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN
Type:
Protein
Mol. Mass.:
42941.16
Organism:
Homo sapiens (Human)
Description:
Q9NXS2
Residue:
382
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
  
Inhibitor
Name:
BDBM124974
Synonyms:
US8772508, 8
Type:
Small organic molecule
Emp. Form.:
C16H27N5O2
Mol. Mass.:
321.4179
SMILES:
Cc1cncn1CCCCN\C(NC1CCCCC1)=C/[N+]([O-])=O
Structure:
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