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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM125192
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
pH
6±n/a
IC50
1370±n/a nM
Comments
extracted
Citation
 Himmelsbach, F Azaspirohexanones US Patent  US8765744 Publication Date 7/1/2014 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM125192
Synonyms:
US8765744, 99
Type:
Small organic molecule
Emp. Form.:
C17H23NO3
Mol. Mass.:
289.3694
SMILES:
C[C@H](N1CC[C@]2(CC[C@H](O)CC2)OC1=O)c1ccccc1 |r,wU:5.4,1.0,wD:5.12,8.8,(2,-1.34,;2,-2.88,;.67,-3.65,;.67,-5.19,;-.67,-5.96,;-2,-5.19,;-2,-6.73,;-3.33,-7.5,;-4.67,-6.73,;-6,-7.5,;-4.67,-5.19,;-3.33,-4.42,;-2,-3.65,;-.67,-2.88,;-.67,-1.34,;3.33,-3.65,;3.33,-5.19,;4.67,-5.96,;6,-5.19,;6,-3.65,;4.67,-2.88,)|
Structure:
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