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Target
Mitogen-activated protein kinase 14
Ligand
BDBM125995
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1.4±n/a nM
Citation
 Eastwood, PR; Gonzalez Rodriguez, J; Vidal Juan, B; Aguilar Izquierdo, N Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors US Patent  US8772288 Publication Date 7/8/2014 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM125995
Synonyms:
US8772288, 34
Type:
Small organic molecule
Emp. Form.:
C24H26N2O3
Mol. Mass.:
390.4748
SMILES:
Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(O)CC2)c1)C(=O)NC1CC1 |(-4.1,1.33,;-2.77,2.1,;-2.77,3.64,;-1.44,4.41,;-.1,3.64,;-.1,2.1,;-1.44,1.33,;-1.44,-.21,;-.1,-.98,;-.1,-2.52,;-1.44,-3.29,;-2.77,-2.52,;-3.91,-3.55,;-3.29,-4.95,;-4.06,-6.29,;-1.76,-4.79,;-2.16,-6.28,;-1.07,-7.37,;.42,-6.97,;1.51,-8.06,;.82,-5.48,;-.27,-4.39,;-2.77,-.98,;1.23,4.41,;2.56,3.64,;1.23,5.95,;2.56,6.72,;4.1,6.72,;3.33,8.06,)|
Structure:
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