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Target
Mitogen-activated protein kinase 14
Ligand
BDBM125997
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1±n/a nM
Citation
 Eastwood, PR; Gonzalez Rodriguez, J; Vidal Juan, B; Aguilar Izquierdo, N Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors US Patent  US8772288 Publication Date 7/8/2014 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM125997
Synonyms:
US8772288, 40
Type:
Small organic molecule
Emp. Form.:
C28H33N3O3
Mol. Mass.:
459.5799
SMILES:
Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(CC2)N2CCOCC2)c1)C(=O)NC1CC1 |(-4.77,3.67,;-3.44,4.44,;-3.44,5.98,;-2.1,6.75,;-.77,5.98,;-.77,4.44,;-2.1,3.67,;-2.1,2.13,;-.77,1.36,;-.77,-.18,;-2.1,-.95,;-3.44,-.18,;-4.58,-1.21,;-3.96,-2.61,;-4.73,-3.95,;-2.42,-2.45,;-2.82,-3.94,;-1.73,-5.03,;-.25,-4.63,;.15,-3.14,;-.94,-2.05,;.84,-5.72,;.44,-7.21,;1.53,-8.29,;3.02,-7.9,;3.42,-6.41,;2.33,-5.32,;-3.44,1.36,;.56,6.75,;.56,8.29,;1.9,5.98,;3.23,6.75,;4,8.09,;4.77,6.75,)|
Structure:
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