Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM126000
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
8±n/a nM
Citation
 Eastwood, PR; Gonzalez Rodriguez, J; Vidal Juan, B; Aguilar Izquierdo, N Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors US Patent  US8772288 Publication Date 7/8/2014 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM126000
Synonyms:
US8772288, 65
Type:
Small organic molecule
Emp. Form.:
C24H25FN4O2
Mol. Mass.:
420.4793
SMILES:
Cc1nnc([nH]1)-c1cc(F)c(C)c(c1)-c1ccc2c(NC(=O)C22CCC(C)(O)CC2)c1 |(3.72,8.14,;2.95,6.8,;3.85,5.56,;2.95,4.31,;1.48,4.79,;1.48,6.33,;.15,4.02,;-1.18,4.79,;-2.52,4.02,;-3.85,4.79,;-2.52,2.48,;-3.85,1.71,;-1.18,1.71,;.15,2.48,;-1.18,.17,;.15,-.6,;.15,-2.14,;-1.18,-2.91,;-2.52,-2.14,;-3.66,-3.17,;-3.04,-4.58,;-3.81,-5.91,;-1.51,-4.42,;-1.9,-5.91,;-.81,-7,;.67,-6.6,;.67,-8.14,;2.01,-7.37,;1.07,-5.11,;-.02,-4.02,;-2.52,-.6,)|
Structure:
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