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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM143302
Substrate
n/a
Meas. Tech.
FAAH Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
7.00±n/a nM
Comments
extracted
Citation
 Kharul, R; Bhuniya, D; Mookhtiar, KA; Singh, U; Hazare, A; Patil, S; Datrange, L; Thakkar, M Amide compounds, compositions and applications thereof US Patent  US9682953 Publication Date 6/20/2017 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM143302
Synonyms:
US9682953, 5.A-6
Type:
Small organic molecule
Emp. Form.:
C28H24F3N5O4S
Mol. Mass.:
583.581
SMILES:
FC(F)(F)S(=O)(=O)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-n3cccn3)c2)nc1 |(-13.63,-5.51,;-12.29,-6.28,;-12.29,-7.82,;-13.54,-7.19,;-10.96,-5.51,;-10.96,-3.97,;-10.96,-7.05,;-9.62,-6.28,;-8.29,-5.51,;-6.96,-6.28,;-6.96,-7.82,;-5.62,-8.59,;-4.29,-7.82,;-4.29,-6.28,;-2.96,-5.51,;-1.62,-6.28,;-1.62,-7.82,;-.29,-8.59,;1.05,-7.82,;2.38,-8.59,;3.71,-7.82,;3.71,-6.28,;2.38,-5.51,;1.05,-6.28,;5.19,-5.51,;6.52,-6.28,;6.52,-7.82,;7.86,-5.51,;9.19,-6.28,;10.53,-5.51,;10.53,-3.97,;9.19,-3.2,;7.86,-3.97,;12.1,-3.1,;13.51,-3.73,;14.54,-2.59,;13.77,-1.25,;12.26,-1.57,;-2.96,-8.59,;-8.29,-8.59,;-9.62,-7.82,)|
Structure:
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