Reaction Details
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Histamine H3 receptor
Ligand
BDBM128117
Substrate
n/a
Meas. Tech.
Competition Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
12.3±n/a nM
Comments
extracted
Citation
Black, LA; Gfesser, GA; Cowart, MD 4-substituted-2-amino-pyrimidine derivatives US Patent US8796297 Publication Date 8/5/2014 More Info.:
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
Inhibitor
Name:
BDBM128117
Synonyms:
US8796297, 23
Type:
Small organic molecule
Emp. Form.:
C11H17N5
Mol. Mass.:
219.2862
SMILES:
Nc1nccc(n1)N1CCC2(CNC2)CC1
Structure:
