Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM44773
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
102969±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM44773
Synonyms:
MLS000103167 | N-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]cyclopropanecarboxamide | N-[4-(3-methoxyphenyl)-2-thiazolyl]cyclopropanecarboxamide | N-[4-(3-methoxyphenyl)thiazol-2-yl]cyclopropanecarboxamide | SMR000018616 | cid_4673629
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2S
Mol. Mass.:
274.338
SMILES:
COc1cccc(c1)-c1csc(NC(=O)C2CC2)n1
Structure:
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