Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128213
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128213
Synonyms:
MLS000545606 | N'-[(1-ethyl-5-methyl-1H-pyrazol-4-yl)methylene]-1-benzothiophene-3-carbohydrazide | N-[(Z)-(1-ethyl-5-methyl-4-pyrazolyl)methylideneamino]-1-benzothiophene-3-carboxamide | N-[(Z)-(1-ethyl-5-methyl-pyrazol-4-yl)methyleneamino]benzothiophene-3-carboxamide | N-[(Z)-(1-ethyl-5-methyl-pyrazol-4-yl)methylideneamino]-1-benzothiophene-3-carboxamide | N-[(Z)-(1-ethyl-5-methylpyrazol-4-yl)methylideneamino]-1-benzothiophene-3-carboxamide | SMR000159916 | cid_5412241
Type:
Small organic molecule
Emp. Form.:
C16H16N4OS
Mol. Mass.:
312.389
SMILES:
CCn1ncc(\C=N/NC(=O)c2csc3ccccc23)c1C
Structure:
Search PDB for entries with ligand similarity: