Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128215
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128215
Synonyms:
MLS000595230 | N-aminocarbonyl-2-(4-azanylidenequinolin-1-yl)ethanamide;hydrochloride | N-carbamoyl-2-(4-imino-1-quinolinyl)acetamide;hydrochloride | N-carbamoyl-2-(4-imino-1-quinolyl)acetamide;hydrochloride | N-carbamoyl-2-(4-iminoquinolin-1-yl)acetamide;hydrochloride | SMR000149753 | [2-(4-Imino-4H-quinolin-1-yl)-acetyl]-urea | cid_11957159
Type:
Small organic molecule
Emp. Form.:
C12H13ClN4O2
Mol. Mass.:
280.71
SMILES:
Cl.NC(=O)NC(=O)Cn1ccc(=N)c2ccccc12
Structure:
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