Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128238
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128238
Synonyms:
2-(9-benzyl-1,7-dimethyl-2,4-dioxo-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)acetamide | 2-(9-benzyl-2,4-diketo-1,7-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)acetamide | 2-[1,7-dimethyl-2,4-bis(oxidanylidene)-9-(phenylmethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl]ethanamide | 2-[1,7-dimethyl-2,4-dioxo-9-(phenylmethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl]acetamide | MLS001166760 | SMR000641393 | cid_16614245
Type:
Small organic molecule
Emp. Form.:
C19H22N6O3
Mol. Mass.:
382.4164
SMILES:
CC1CN(Cc2ccccc2)c2nc3n(C)c(=O)n(CC(N)=O)c(=O)c3n2C1
Structure:
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