Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128244
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
62969±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128244
Synonyms:
KUC104959 | MLS003116436 | SMR001831989 | [(2R,4R,5R)-5-[4-(4-fluorophenyl)-1,2,3-triazol-1-yl]-2-(4-methylphenyl)-4-oxidanyl-piperidin-1-yl]-thiophen-2-yl-methanone | [(2R,4R,5R)-5-[4-(4-fluorophenyl)-1-triazolyl]-4-hydroxy-2-(4-methylphenyl)-1-piperidinyl]-thiophen-2-ylmethanone | [(2R,4R,5R)-5-[4-(4-fluorophenyl)triazol-1-yl]-4-hydroxy-2-(4-methylphenyl)piperidin-1-yl]-thiophen-2-ylmethanone | [(2R,4R,5R)-5-[4-(4-fluorophenyl)triazol-1-yl]-4-hydroxy-2-(p-tolyl)piperidino]-(2-thienyl)methanone | cid_46903185
Type:
Small organic molecule
Emp. Form.:
C25H23FN4O2S
Mol. Mass.:
462.539
SMILES:
Cc1ccc(cc1)[C@H]1C[C@@H](O)[C@@H](CN1C(=O)c1cccs1)n1cc(nn1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: