Reaction Details Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM129721
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
>1000±n/a nM
Citation
 Szalai, GB; Csongor, EA; Domany, G; Gyertyan, I; Kiss, B; Laszy, J; Saghy, K; Schmidt, E; Farkas, S; Komlodi, Z Pyrimidinyl-piperazines useful as D3/D2 receptor ligands US Patent  US8802672 Publication Date 8/12/2014 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A
Type:
Protein
Mol. Mass.:
51620.15
Organism:
Rattus norvegicus (Rat)
Description:
P43140
Residue:
466
Sequence:
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
  
Inhibitor
Name:
BDBM129721
Synonyms:
US8802672, 11
Type:
Small organic molecule
Emp. Form.:
C20H32Cl2N6O
Mol. Mass.:
443.414
SMILES:
CNc1nc(Cl)c(Cl)c(n1)N1CCN(CCC2CCC(CCC(N)=O)CC2)CC1 |(-2.67,-18.48,;-4,-19.25,;-5.33,-18.48,;-6.67,-19.25,;-8,-18.48,;-9.34,-19.25,;-8,-16.94,;-9.34,-16.17,;-6.67,-16.17,;-5.33,-16.94,;-6.67,-14.63,;-5.33,-13.86,;-5.33,-12.32,;-6.67,-11.55,;-6.67,-10.01,;-8,-9.24,;-8,-7.7,;-6.67,-6.93,;-6.67,-5.39,;-8,-4.62,;-8,-3.08,;-9.34,-2.31,;-9.34,-.77,;-8,,;-10.67,,;-9.34,-5.39,;-9.34,-6.93,;-8,-12.32,;-8,-13.86,)|
Structure:
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