Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM285474
Substrate
n/a
Meas. Tech.
EP4 Antagonistic Activity Measurement
Temperature
298.15±n/a K
IC50
3.40±n/a nM
Comments
extracted
Citation
 Asada, M; Tani, K; Hirobe, M; Higuchi, S; Fuchibe, K; Oikawa, R; Kotani, T; Takano, H Tricyclic spiro compound US Patent  US10077247 Publication Date 9/18/2018 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM285474
Synonyms:
4-[4-Cyano-2-({[(2′R,4S)-6-(1,2-oxazol-3-ylcarbamoyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid | US10077247, Example 2-37
Type:
Small organic molecule
Emp. Form.:
C27H24N4O6
Mol. Mass.:
500.5027
SMILES:
OC(=O)CCCc1ccc(cc1NC(=O)[C@@H]1C[C@]11CCOc2ccc(cc12)C(=O)Nc1ccon1)C#N |r|
Structure:
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