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Target
Nitric oxide synthase, endothelial [1-973,Y477A]
Ligand
BDBM130384
Substrate
n/a
Meas. Tech.
Spectral Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Kd
3.49e+3± 2.4e+2 nM
Comments
extracted
Citation
 Li, H; Jamal, J; Delker, S; Plaza, C; Ji, H; Jing, Q; Huang, H; Kang, S; Silverman, RB; Poulos, TL The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry 53:5272-9 (2014) [PubMed]  Article 
Target
Name:
Nitric oxide synthase, endothelial [1-973,Y477A]
Synonyms:
NOS3 | NOS3_BOVIN | Nitric oxide synthase mutant (eNOS Y477A)
Type:
Protein
Mol. Mass.:
107246.46
Organism:
Bos taurus (bovine)
Description:
Bovine endothelial nitric oxide synthase mutant Y477A
Residue:
973
Sequence:
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPTLTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRAQPDPWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKAAAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPGGPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVAVLAYRTQDGLGPL
  
Inhibitor
Name:
BDBM130384
Synonyms:
6({[(2R,4S)4{[(6amino4methylpyridin2 yl)oxy]methyl}pyrrolidin2yl]methoxy}methyl)4 methylpyridin2amine ((2R,4S)-6)
Type:
Small organic molecule
Emp. Form.:
C19H27N5O2
Mol. Mass.:
357.45
SMILES:
Cc1cc(N)nc(COC[C@H]2C[C@H](COc3cc(C)cc(N)n3)CN2)c1 |r|
Structure:
Search PDB for entries with ligand similarity: