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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM130689
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Temperature
280.65±n/a K
IC50
34.6±n/a nM
Citation
 Chen, Z; De Lombaert, S; Dines, JA; Liu, W; Lo, HY; Loke, PL Benzimidazole inhibitors of leukotriene production US Patent  US8829200 Publication Date 9/9/2014 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM130689
Synonyms:
US8829200, 26
Type:
Small organic molecule
Emp. Form.:
C25H28N6O
Mol. Mass.:
428.5294
SMILES:
CC(C)NC(=O)c1ccccc1-c1nc2cc(ccc2n1C(C)(C)C)-c1cnc(N)nc1
Structure:
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