Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase receptor R3
Ligand
BDBM130919
Substrate
n/a
Meas. Tech.
In Vitro Kinase Activity Assay
pH
7.5±n/a
IC50
9.157±n/a nM
Comments
extracted
Citation
 Gregor, VE Tyrosine kinase inhibitors US Patent  US8822500 Publication Date 9/2/2014 
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1)
Type:
Enzyme
Mol. Mass.:
56134.46
Organism:
Homo sapiens (Human)
Description:
P37023
Residue:
503
Sequence:
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
  
Inhibitor
Name:
BDBM130919
Synonyms:
US8822500, [18]
Type:
Small organic molecule
Emp. Form.:
C27H28F2N6O2
Mol. Mass.:
506.547
SMILES:
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3CN(CCN(C)C)C(=O)c3cc2[nH]1
Structure:
Search PDB for entries with ligand similarity: