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Target
G-protein coupled receptor 6
Ligand
BDBM190939
Substrate
n/a
Meas. Tech.
Inhibition of cAMP Activity of GPR6 In Vitro A.2 Assay
IC50
6600±n/a nM
Citation
 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent  US10077266 Publication Date 9/18/2018 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM190939
Synonyms:
US10077266, Example 51 | US9181249, 51 | US9708313, 51
Type:
Small organic molecule
Emp. Form.:
C24H29F4N5O3
Mol. Mass.:
511.5124
SMILES:
CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F |r|
Structure:
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