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Target
Cyclin-dependent kinase 6
Ligand
BDBM132299
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
500±n/a nM
Citation
 Connors, RV; Kang, D; Eksterowicz, J; Fan, P; Fisher, B; Fu, J; Li, K; Li, Z; McGee, LR; Sharma, R; Wang, X; McMinn, DL; Mihalic, JT; Deignan, J Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors US Patent  US8841312 Publication Date 9/23/2014 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM132299
Synonyms:
US8841312, 42
Type:
Small organic molecule
Emp. Form.:
C24H28N8O
Mol. Mass.:
444.5321
SMILES:
COc1cc2c(cn1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21
Structure:
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