Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50329610
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
5.9±n/a nM
Citation
Anderson, AC; Wright, DL; Frey, KM; Paulsen, JL; Scocchera, EW; Viswanathan, K Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase US Patent US8853228 Publication Date 10/7/2014
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
19690.71
Organism:
Streptococcus pyogenes
Description:
J7IFZ2
Residue:
165
Sequence:
MKVSLIAAMDKNRVIGKENDIPWRIPKDWEYVKNTTKGHPIILGRKNLESIGRALPDRRNIILTRDKGFTFNGCEIVHSIEDVFELCKNEEEIFIFGGEQIYNLFFPYVEKMYITKIHHEFEGDTFFPEVNYEEWNEVFAQKGIKNDKNPYNYYFHVYERKNLLS