Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM285644
Substrate
n/a
Meas. Tech.
Human D1 Receptor Binding Assay
pH
7.4±n/a
Ki
32.7±n/a nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Davoren, JE; Dounay, AB; Efremov, IV; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US10077272 Publication Date 9/18/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM285644
Synonyms:
4,6-Dimethyl-5-[2-methyl-4-([1,2]thiazolo[4,5-c]pyridin-4-yloxy)phenyl]pyridazin-3(2H)- | US10077272, Example 10 | US9868744, 10
Type:
Small organic molecule
Emp. Form.:
C19H16N4O2S
Mol. Mass.:
364.421
SMILES:
Cc1cc(Oc2nccc3sncc23)ccc1-c1c(C)n[nH]c(=O)c1C |(-3.81,-14.36,;-3.81,-15.9,;-5.14,-16.67,;-5.14,-18.21,;-6.48,-18.98,;-6.48,-20.52,;-5.14,-21.29,;-5.14,-22.83,;-6.48,-23.6,;-7.81,-22.83,;-9.27,-23.31,;-10.18,-22.06,;-9.27,-20.82,;-7.81,-21.29,;-3.81,-18.98,;-2.47,-18.21,;-2.47,-16.67,;-1.14,-15.9,;.19,-16.67,;.19,-18.21,;1.53,-15.9,;1.53,-14.36,;.19,-13.59,;.19,-12.05,;-1.14,-14.36,;-2.47,-13.59,)|
Structure:
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