Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM285646
Substrate
n/a
Meas. Tech.
Human D1 Receptor Binding Assay
pH
7.4±n/a
Ki
367±n/a nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Davoren, JE; Dounay, AB; Efremov, IV; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US10077272 Publication Date 9/18/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM285646
Synonyms:
5-[4-(1H-imidazo[4,5-c]pyridin-4-yloxy)-2-methylphenyl]-6-methylpyrimidine-4-carbonitrile | US10077272, Example 12 | US9868744, 12
Type:
Small organic molecule
Emp. Form.:
C19H14N6O
Mol. Mass.:
342.3541
SMILES:
Cc1cc(Oc2nccc3[nH]cnc23)ccc1-c1c(C)ncnc1C#N |(.52,4.23,;.52,2.69,;-.82,1.93,;-.82,.38,;-2.15,-.38,;-2.15,-1.93,;-.82,-2.69,;-.82,-4.23,;-2.15,-5,;-3.48,-4.23,;-4.95,-4.71,;-5.85,-3.47,;-4.95,-2.22,;-3.48,-2.69,;.52,-.38,;1.85,.38,;1.85,1.93,;3.19,2.69,;3.19,4.23,;1.85,5,;4.52,5,;5.85,4.23,;5.85,2.69,;4.52,1.87,;4.52,.33,;4.52,-1.21,)|
Structure:
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