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Target
D(1A) dopamine receptor
Ligand
BDBM285647
Substrate
n/a
Meas. Tech.
Human D1 Receptor Binding Assay
pH
7.4±n/a
Ki
70.3±n/a nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Davoren, JE; Dounay, AB; Efremov, IV; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US10077272 Publication Date 9/18/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM285647
Synonyms:
5-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]-4,6-dimethylpyridazin-3(2H)-one | US10077272, Example 13 | US9868744, 13
Type:
Small organic molecule
Emp. Form.:
C18H14N4O3
Mol. Mass.:
334.3288
SMILES:
Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2ncnc3occc23)cc1
Structure:
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