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Target
D(1A) dopamine receptor
Ligand
BDBM285649
Substrate
n/a
Meas. Tech.
Human D1 Receptor Binding Assay
pH
7.4±n/a
Ki
280±n/a nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Davoren, JE; Dounay, AB; Efremov, IV; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US10077272 Publication Date 9/18/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM285649
Synonyms:
1,5-dimethyl-6-{4-[(3-methyl[1,2]oxazolo[4,5-c]pyridin-4-yl)oxy]phenyl}pyrimidine-2,4(1H,3H)-dione | US10077272, Example 15 | US9868744, 15
Type:
Small organic molecule
Emp. Form.:
C19H16N4O4
Mol. Mass.:
364.3547
SMILES:
Cc1noc2ccnc(Oc3ccc(cc3)-c3c(C)c(=O)[nH]c(=O)n3C)c12
Structure:
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